GY Lee Lab

My team employs an integrative systems biology framework to study two central, interconnected questions critical to public health: (1) how pathogens evolve to evade host defenses and escape our interventions, and (2) how we can leverage this knowledge to develop intervention strategies, ultimately translating this knowledge into first-in-class therapeutics. To this end, my team integrates computational biology and wet experiments , which bridges large-scale computational genomics with experimental validation. By capturing a systems-level view of evolutionary trajectories, my team will uncover the complex adaptive strategies driving pathogenesis, thereby enabling us to anticipate and prepare for potential outbreaks in advance.